Cell and small animal models for phenotypic drug discovery
نویسندگان
چکیده
منابع مشابه
Cell and small animal models for phenotypic drug discovery
The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative platform for drug discovery. This review provides an overview of the various model systems and technical advances in imaging and image analyses that strengthen the PDD platform. In PDD screens, compounds of therapeutic value are identified based on the phenotypic perturbations produced irrespective of target(s) o...
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Drug discovery in its early history used to be conducted mainly in a target-agnostic fashion, focusing on qualitative readouts from a living system -cells, tissue, or organisms -and asking the question, ‘Did this entity affect the phenotype?’. With the rise of molecular biology in the early 1980s and an ever more powerful genomics toolkit from the 1990s, there was a marked shift away from pheno...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2017
ISSN: 1177-8881
DOI: 10.2147/dddt.s129447